MOTS-c (10mg)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-
derived peptide encoded within the mitochondrial genome. It represents a
relatively recently discovered class of signaling peptides with significant
implications in metabolic and longevity research.

Compound Details (per vial):
— MOTS-c: 10mg
— Form: Lyophilized powder
— Purity: ≥98%

MOTS-c is one of the first identified mitochondria-derived peptides (MDPs)
to demonstrate systemic endocrine signaling activity. Its primary mechanism
involves activation of the AMPK pathway through modulation of the folate
cycle and de novo purine synthesis, driving downstream effects on glucose
utilization and insulin sensitivity in skeletal muscle research models.
Studies have demonstrated that MOTS-c acts as a mitochondrial stress signal
that translocates to the nucleus under metabolic stress conditions, where it
regulates nuclear gene expression related to energy homeostasis. Research has
also examined its role in aging biology, where MOTS-c levels have been shown
to decline with age in human studies, and its supplementation in aged murine
models restored metabolic flexibility and physical capacity. Additional research
has focused on its anti-inflammatory properties and its interaction with the
NAD+ biosynthesis pathway, making it a compound of significant interest in
longevity and metabolic dysfunction research.

Supplied lyophilized in a sterile sealed vial. Third-party tested for identity
and purity prior to release. Not for human consumption. For research use only.